The United States Department of Defense (DoD) awarded David M. Loeb, MD, PhD, Chief, Division of Pediatric Hematology, Oncology and Cellular Therapy, Director, Sarcoma Program, Children’s Hospital at Montefiore (CHAM), and Professor, Pediatrics and Developmental and Molecular Biology, Albert Einstein College of Medicine, a $400,000, two-year Idea Award grant to explore treatment-induced metastasis in a rare form of bone cancer.
Idea Award grants support innovative, paradigm-challenging, potentially high-risk/high-reward cancer research, such as Dr. Loeb’s proposal, titled “Treatment-Induced Metastasis in Ewing Sarcoma.” Using the DoD funding, Dr. Loeb will test his novel hypothesis that first treatments of chemotherapy and radiation therapy increase the spread of sarcoma cells from a primary tumor, and this can be countered by therapies targeting the function of tumor-associated macrophages or endothelial cells.
